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Our expertise

Experienced and passionate
Brainclinics offers almost twenty years of experience with rTMS, neurofeedback, EEG and QEEG and we consider ourselves to be not merely up-to-date but in the forefront of developments in these fields. The scientific research by our own research institute in our own state of the art laboratory is world renowned.
We’re passionate about brains, and it shows.

We care
We can support you with our knowledge and experience in the acquisition and callibration of equipment to furnish your lab or treatment facility. After you’ve set up your facility we’re always on call, should you need help or further advice.
We care for what we do, and we care about you.

Working with Brainclinics means you will benefit from our expertise and will enable you to provide your clients with the best assessment and best possible treatment options.

Turnkey Laboratory Solutions

Research equipment
In scientific research, especially under laboratory conditions, consistency is key.
The Brainclinics Research Institute offers almost two decades of experience in setting up and maintaining ideal test environments, ensuring that your assessments are valid, precise and correct.

Treatment conditions
The right environment is also very important when treating clients. They should be comfortable and at home with their surroundings, feel at ease and safe. Your equipment is important: it should be unobtrusive, operate quietly and be extremely reliable.
We constantly evaluate and review the equipment we choose for ourselves or recommend to others and you can be confident of the fact that we will give you the best possible advice and offer the best solutions.

We provide solutions
Our experts understand your needs and will work with you to ensure your lab set up or treatment facility is ideally suited to your circumstances.

QEEG brainmapping

What isQEEG?
QEEG is an acronym for Quantitative ElectroEncephaloGraph, or to use a more popular term: brainmapping. It can be used to identify neuromarkers or EEG phenotypes in a range of psychiatric disorders such as MCI (Mild Cognitive Impairment), Alzheimer’s, dementia, ADHD, schizophrenia, PTSD, depression, etc.

Assessing data
Besides the presence of a wide range of diagnostic groups in a database, it is also important to have a good normative reference frame. For this we have and provide access to a normative database of more than 20,000 healthy subjects and large patient groups (ADHD, depression, etc.) which include Neurophysiological and Neuropsychological (IntegNeuro) data.

At the Brainclinics Research Institute we apply deep learning to help you determine the best protocol in the treatment of a wide range of psychiatric disorders or, for instance, investigate the effect of comorbidities, which makes our method a valuable tool for personalized medicine.
QEEG is also great to advance Applied Brain Research.
At Brainclinics we’re very excited to offer our expertise to you!

Become a partner in a large network
Our network encompasses clinics around the world and the wealth of data they produce are a valuable asset for applied brain research. We’d love it if you would join us and are happy to offer advice to help you set up your own QEEG lab. Please contact us directly via mail to discuss the possibilities and advantages of joining our network.

History of QEEG research
Did you know that QEEG has a long history? Of course it all started with the first EEG’s back in the 1930’s, but we have Ross Adey of the UCLA Brain Research Institute to thank for the use of QEEG, because he pioneered that research in the 1960’s. There’s a short article about that on our site.
Would you like to know more? The very enjoyable book neurofeedback, how it all started gives an extensive, highly readable and sometimes surprising account of the history of the EEG and QEEG. Get it while stocks last!

Current QEEG practice
Take a look at this page if you’d like to learn more about the QEEG procedure.

The QEEG procedure

The BRC QEEG Procedure: Clients are assessed (non-invasive) while measuring their brain function. The brain is measured by picking up electrical streams (brain activity) that run over the skull – the so-called QEEG or Quantitative electroencephalogram – added with neuropsychological tests. The following sizes are synchronously recorded during the QEEG Research: 25 channels EEG, skin resistance (SCL, SCR or GSR), brain potentials (QEEG, ERP – Event Related Potentials), derivatives of the autonomic nervous system (ANS: heart rate, respiration) and motor response e.g. reaction time.

While the client is connected, activation tests are assessed, each of which relate to a functional network in the brains. These measurements provide information – with millisecond time resolution – on the processing of this information in the brains. We use the following specific tests in our QEEG research:

Resting EEG
The subject is asked to sit quietly and focus on the red dot (eyes open) followed by an eyes closed task.
Reflects: A baseline of brain and body measures.

Habituation
The subject listens passively to auditory stimuli.
Reflects: Brain-body response decrements to novel stimuli, indicative of automatic learning.

Auditory oddball
The subject is presented with tones and is required to ignore the low tones, and press a response button only when one hears the infrequent high tones.
Reflects: Capacity to process relevant whilst ignoring irrelevant information.

Visual tracking
A red dot moves smoothly (horizontally) on the screen at a frequency of 0.4Hz. The subject is required to visually track the dot as it moves.
Reflects: Eye tracking and brain function during an automatic tracking task.

Go-No Go
The colour of the word ‘PRESS’ is presented randomly in either red or green. The subject is required to press a response button when they see the word ‘PRESS’ in green, but not to press the button when the word ‘PRESS’ is in red.
Reflects: Capacity for suppressing well-learned, automatic responses.

Conscious and subconscious processing of facial emotions
A series of facial expressions displaying different emotions is presented, which the subject is required to process and rate.
Reflects: Emotion recognition.

Visual working memory
A series of letters is presented on the screen one by one. The subject is required to press a response button if the same letter appears twice in a row.
Reflects: Sustained attention and working memory.

Executive maze
A dot-based maze is presented on the screen. Using a button box, the subject is required to learn to find (by trial and error) a hidden path through the maze.
Reflects: Planning, error correction, visuo-spatial learning and memory.

Startle
A series of loud tones are presented, half without warning, half with a pre-pulse.
Reflects: The body’s ‘fight or flight’ response.

Both the brain (QEEG) and neuropsychological tests each take less than an hour and the task instructions are very simple and easy to understand. Including some additional questionnaires and ‘application of the cap’ the assessment takes about 3 hours . All tests are used for all ages, making the database ‘assumption free’, which the natural development of a test on different age can be followed perfectly.

Reliability and validity of these tests is good and were also published.
For a good example of neuromarkers in ADHD you can download a detailed example
Download some examples of QEEG and neuropsychological reports:
Sample QEEG report: Personalized Medicine NEW incl. all ERP’s
Sample QEEG report: Raw Data – clear beta spindles

BRC has an FDA approval for the 510 K used QEEG hardware and is FDA approved

rTMS equipment

What is rTMS?
rTMS stands for Repetitive Transcranial Magnetic Stimulation or repetitive magnetic brain stimulation. When applying rTMS, a coil is put at a precise and particular location on the head. The strong magnetic field generated by the coil is converted into pulses which exit the device and then easily penetrates through the skull to reach the brain. These pulses can, because they are strongly magnetic, stimulate certain sections of the brain and can reinforce communication in certain functional networks. rTMS is for example used in the treatment of depressive symptoms. For more literature about rTMS, click here. You can find more information about rTMS in practice here.

We listen
Our experience with carrying out rTMS treatments is beyond equal. We pioneered the technique in The Netherlands and have refined and improved our methods to the point of perfection. We’ve seen equipment evolve over time, and were vital in the development of current iterations. We’ve never been shy in calling manufacturers when it comes to improving their equipment.
Our feedback matters, manufacturers listen. And we listen to you.

More information?
The devices that we work with are best-in-show, and of course they’re medical CE approved. We’ll describe them in short below.
If you are interested to apply rTMS in your own practice, or have further questions, please contact us for advice, and of course we’d be happy to provide you with a quotation too.
Would you like a training package tailored to your needs? We’ve got you covered.

Deymed DuoMag XT

This equipment has been developed recently and is based on the latest technical insights.
The DuoMag rTMS equipment can be used for different rTMS treatment protocols as well as scientific research. There are 3 models to cover your needs. In general, these are all rTMS devices with a bi-phasic pulse. You can download the brochure here.

Product specsDuoMAg XT10DuoMAg XT35DuoMAg XT100
Pulse modusBi-phasic, repetitiveBi-phasic, repetitiveBi-phasic, repetitive, burst
Dimensions49x16x38cm49x16x38cm49x16x38cm
Weight17kg17,5kg17,5kg
Stimulation intensity 100%5Hz13Hz22Hz
Stimulation intensity  50% *10Hz35Hz80Hz
Max. repetitive rate20Hz50Hz100Hz
Min. interstimulus interval in trainmodus1ms1ms11ms
Pulse width290μs290μs290μs
Coil compatibilityDeymed coilsDeymed coilsDeymed coils
Voltage100-240Vac 50/60Hz100-240Vac 50/60Hz100-240Vac 50/60Hz
SynchronisationTTL in/out and/or USBTTL in/out and/or USBTTL in/out and/or USB
CommunicationUSB full control on coilUSB full control on coilUSB full control on coil

* The motor threshold (MT), which is found on 47% stimulation intensity on all of the devices for the largest part of the population (> 90%)

Further functionality:

  • Equipped with special air-cooled 8-shaped coil for daily use (other coils such as a double-cone coil also available separately)
  • Easily moveable and manageable and fix flushing arm
  • Touch-screen interface and user friendly software based on Windows
  • Stimulation intensity and start-stop can be set on the coil for ease of use
  • Installed on a Deymed trolley with wheels so it is easy to move from room to room or within a room

MagStim Rapid2 rTMS stimulator with AirFilm coil

The Magstim Rapid ² is a repetitive stimulator with high frequency capabilities that can also be used for single-pulse protocols. This equipment is suitable for therapeutic purposes as well as research purposes, and is currently the most commonly used equipment in research. You can download a product brochure of the Magstim Rapid2 here.

Product specsMagstim Rapid2 (single PSU)Magstim Rapid2 (dual PSU)
Pulse modusBi-phasic, repetitiveBi-phasic, repetitive
Stimulation intensity  100%15Hz41Hz
Stimulation intensity 50%30Hz97Hz
Max. repetitive rate50Hz100Hz
Min. interstimulus intervalN/AN/A
Pulse width320μs320μs
Coil compatibilityMagstim coilsMagstim coils
Main voltage1,67kv1,67kv
SynchronisationTTL in/outTTL in/out
CommunicationN/AN/A

Neuro Cardiac Guided TMS

Connecting brain and heart
Many studies suggest a role of the connectivity of the dorsolateral prefrontal cortex (DLPFC) and the subgenual anterior cingulate cortex (sgACC) in depression. Prior research has demonstrated that neuromodulation of either of these nodes modulates parasympathetic activity and results in a heart rate deceleration. A new method called Neuro-Cardiac Guided rTMS helps to adequately target the DLPFC- sgACC network.
A groundbreaking thesis on this very interesting subject by one of our researchers can be found and downloaded at no cost here

NCG-ENGAGE is a biofeedback system for the NCG-rTMS. Scientists and physicians use NCG-ENGAGE to locate the individual point of maximum heart rate deceleration at the DLPFC.
In the future, NCG-ENGAGE will enable physicians to individualize rTMS therapy for depression and other diseases for patients. The method is intended to help determine the optimal dose of rTMS and provide information on the efficiency of the therapy proposed under NCG-rTMS. Further clinical data are currently being collected.

Features

  • touch display for presenting data and user interaction
  • easy-to-use ECG cable for safe recording during TMS
  • connecting cables for receiving the trigger from different TMS devices
  • TMS trigger and ECG stored on SD card (EDF+ format)

Technical data

  • R wave detection sensitivity 99.9 %
  • R wave specificity 99.1 % (own data bases without TMS artefacts)
  • 24 bit resolution / SNR > 90 dB / noise RTI < 15 μVpp
  • ECG input for neuroConn‘s ECG cable
  • input for medical DC power supply
  • trigger input (BNC 5V TTL)
  • SD card: speed class ≥ 10 / memory capacity ≥ 16 GB / reading speed ≥ 90 MB/s / writing speed ≥ 45 MB/s

About Neuroconn
neuroConn is a leading technology brand from Germany. For over ten years they have been associated with practice-oriented medical technology used in neuroscience and clinical research, as well as in the diagnosis and treatment of neuropsychological disorders.
In close cooperation with leading research institutions and clinics worldwide, neuroConn technology is designed following the latest medical research standards, providing users with standardized and clinically evaluated protocols, based on a commitment to quality.
neuroConn offers their technology as complete, ready-to-use systems (neurofeedback and EEG). Additionally, systems can be customized and variably adjusted to the researcher or practitioner’s needs.

Interested in this revolutionary technology? Please contact us for further enquiries.
Download the NCG-Engage datasheet.

Custom rTMS chair

Safe and Durable
Our rTMS chairs are upholstered in a durable, high quality composite synthetic leather with anti-microbial, anti-bacterial and anti-mycotic properties. The multi layered coating offers durability and exceptional resistance to abrasion and UV. These chairs are ideally suited for intensive use and very easy to clean.

Mission
Ensuring your client’s comfort while also enhancing the rTMS treatment: that was the mission we set out accomplish when we rethought the idea of our rTMS chair. The sturdy stainless steel neck support base is completely adjustable (up/down, forward/backward, sideways and rotation/angle) using just one easily manipulatable lever. The support “pillow” itself is comfortably soft and very easy to clean.

This versatility ensures a reclining position that is very relaxing for your client, and provides ideal circumstances for rTMS treatment: a relaxed client will not be fidgety and won’t move around a lot, thus greatly improving coil positioning and pulse targeting without the use of restraints.

Development
This chair is specially designed and customized by Brainclinics for the treatment of clients with rTMS.
We asked our clients to evaluate their comfort or discomfort during treatment and applied their feedback to the ergonomic design of the chair and especially the neck support. During the prototyping phase we tested many different forms before choosing the perfect design.

Options
Our comfortable, versatile and easily adjustable rTMS chair is available in many colors, while we also offer arm rests and swivel wheels as options.
Please contact us for pricing and shipping.
Note: colors on product photos are an approximation and not an exact match.

Chair K83
Upholstered in a beautiful wine red color - code K83
Chair K87
A cheerful bright red - code K87
Chair K93
A happy bright orange - code K93
Chair K82
The sun always shines: yellow - code K82
Chair K81
A nice bright green - code K81
Chair K80
goodbye, blue monday: bright blue- code K80
Chair K89
A tasteful dark blue - code K89
Chair K84
purple rain - code K84
Chair K95
neutral, yet distinctive: grey - code K95
Chair K85
when simply grey just doesn't cut it: anthracite - code K85
Chair K05
black is the new... black - code K05
Chair K11
classy black faux leather - code K11
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Neuropsychological tests: IntegNeuro

IntegNeuro ™ is a user friendly, fully computerized neuropsychological test battery. IntegNeuro provides an individual cognitive performance profile. The obtained data are compared with the International Brain Database of Brain Resource Company currently dates contains more than 20,000 people. This neuropsychological test battery is available in Dutch, English, Spanish and Hebrew.

An intuitive touch screen monitor is combined with simple task instructions, which allows these neuropsychological tests to assess people aged 6-96 years. Full automation ensures a reliable and replicable test results and clear reporting. The validity and reliability of these tests is assessed as well and published in an international scientific journal.

IntegNeuro ™ is ideal for obtaining an individual cognitive profile for a wide range of applications (see also the BRC IntegNeuro product brochure for more details, or the sample reports below), including neuropsychological assessment, evaluation of the effectiveness of (pharmacological) treatment, memory clinics (memory clinics), follow-up of geriatric patients, diagnosis of Alzheimer’s dementia, etc.

Cognition reflects ‘real world’ features such as sensory-motor, memory, attention, language and planning capacities. The IBM touchscreen provides a comprehensive analysis because any contact with the screen will be captured and becomes important additional information about the performance of the client in the response times and variability of responses, above the old paper-and-pencil tests. As a result, IntegNeuro is able to the pick up subtle cognitive problems and / or differences by the use of the touchscreen.

In addition, the tests run automaticly and this provides a standardized reporting of test results. In total, the test battery consists of 13 sub-tests which in total takes about 60 minutes.

Motor tapping
The subject is required to tap in a circle with the index finger of each hand, as fast as possible.
Reflects: Hand-eye coordination and fine movement speed (manual dexterity).

Choice reaction-time
One of four circles lights up and the subject has to tap the lit circle as quickly as possible.
Reflects: Reaction time to stimulus, vigliance.

Timing
A circle lights up for 1 to 12 seconds, subsequently the subject is required to indicate the correct duration.
Reflects: Ability to accurately estimate time

Span of Visual Memory | Corsi Blocks
The subject is required to press a series of squares on the screen in the order in which they previously lit up.
Reflects: Spatial working memory capacity.

Spot The Real Word
A real word is presented simultaneously with a nonsense word. Select the real word.
Reflects: Language comprehension and estimation of premorbid Intelligence Quotient.
note: Only available in English

Digit span
The subject is presented with a sequence of digits and has to repeat them in either forward or backward order.
Reflects: Numerical working memory capacity.

Memory Recall and Recognition
The subject has to recall a set of words after various time intervals and later recognise the words from a list of repeated and new words.
Reflects: Ability for new auditory-verbal learning, recall and recognition.

Verbal Interference
The subject is required to name the colour a word is written in, and not read the actual word.
Reflects: Ability to suppress unwanted, well-learned automatic responses.

Word Generation
The subject is required to say as many words as possible (in 1 min.) which start with a given letter.
Reflects: Verbal fluency.

Switching of Attention | Trailmaking A + B
Numbers and letters are connected in various sequences.
Reflects: Ability to shift the course of ongoing mental activity, attention.

IntegNeuroTM is the Psychometrics test battery, added with these 4 tests below

Emotional recall and recognition
A series of facial expressions displaying different emotions is presented. The subject is required to process and rate the emotions.
Reflects: Emotion recognition.

Executive maze
A dot-based maze is presented on the screen. Using a button box, the subject is required to find (by trial and error) a hidden path through the maze.
Reflects: Planning, error correction, visuo-spatial learning and memory.

Visual working memory
A series of letters is presented on the screen one by one. The subject is required to press a response button if the same letter appears twice in a row, and at no other time.
Reflects: Sustained attention and working memory.

Go–No Go
The colour of the word ‘PRESS’ is presented randomly in either red or green. The subject is required to press the response button only when one sees the word ‘PRESS’ in green but not in red.
Reflects: Capacity for suppressing well learned, automatic responses.

Extra information:

  • Malingering test is withheld and will be assessed random within the test battery
  • “Spot the real word” and “Word Fluency”  are tests that are only available in English

Price informaton:
The price of the Integneuro touchscreen is 1.600 euro (includes headphone, bracket, manual and software). When using it, you pay a fixed amount per report.

For further information and availability of IntegNeuro please contact us.
Ask for special rates IntegNeuro for scientific research!

What we can do for you

We facilitate:

  • complete lab set ups
  • hardware sales
  • software
  • instruction
  • consultancy
  • instruction
  • analysis
  • advice

Our experts can…

  • advise you on setting up your laboratory
  • help in interpreting test results
  • help you calibrate your lab equipment