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The Brainclinics Foundation

Scientific research

Brainclinics was founded in 2001 as an independent research institute by dr. Martijn Arns and specializes in advancing our understanding of the brain; applied neuroscience to advance rTMS techniques, and ADHD and depression research. The results of our research are a valuable aid in the treatment and prevention of symptoms such as mood-, concentration-, impulse control-, and sleep problems, often seen in disorders such as depression, ADHD, and insomnia.

Forward thinking

Over the last 20 years, Brainclinics has pioneered the concept of Stratified Psychiatry, was one of the first to recognize the importance of the circadian clock and sleep problems underlying many symptoms like impaired concentration and impulse control, specifically in ADHD, while also pioneering and refining magnetic brain stimulation (rTMS) in the treatment of depression and obsessive–compulsive disorder (OCD) and in 2017 invented Neuro-Cardiac-Guided TMS to more specifically target the Frontal-Vagal network in Depression. In 2019 the legal structure was changed, and the non-profit Brainclinics Foundation was established.

Mission

The Brainclinics Foundation’s primary mission is best summarized as: Applied Neuroscience from the clinic, to the clinic. Therefore, the two pillars of the foundation are formed by the independent Research Institute Brainclinics and Brainclinics Insights (the publishing division).

applied neuroscience

Personalized medicine

At Research Institute Brainclinics researchers have published over 170 scientific publications on these and related topics and continue to collaborate with researchers and universities around the world ranging from Australia, Germany, Belgium, the United States to Colombia. A key topic of our research revolves around Stratfied Psychiatry and personalised medicine, going beyond the traditional ‘diagnostic-thinking’ and focusing on individual differences that can help optimize and individualize treatment and prevent symptoms from occurring, through the use of Biomarkers.

Brainclinics Insights: Publishing and interactive media

Brainclinics Insights is the publishing division of our foundation. Its mission is to make the knowledge, expertise and especially ‘Insights’ gained through our research, widely available through books, PhD theses and interactive media. As an example, you can here find our latest documentary series titled ‘Pioneers of the EEG’ as well as various books and PhD-theses’ that are also published in the Apple bookstore. If you want to keep up-to-date, also make sure to follow our informative Youtube channel.

To serve the goal of the Brainclinics Foundation, all proceeds are fully invested into Research Institute Brainclinics and Brainclinics Insights, which creates an unprecedented synergy between these divisions and makes it possible to perform research and share new future insights into applied neuroscience as well.

At the Brainclinics Foundation, it is all about the research and its application!

Results

Our research has resulted in 4 patents and several spin-offs, such as Brainquiry, where the first ever wireless Bluetooth based EEG amplifier was developed in 2003 and the first wrist-worn heart-rate device in 2005 (nine years before Apple launched the Apple Watch with similar technology). Other spin-offs are Brainclinics Education, where specialistic applied neuroscience training courses were developed focused on rTMS, neurofeedback and QEEG, and Brainclinics Treatment, where our unequalled knowledge and expertise on personalized neuromodulation treatments are applied to benefit people worldwide. In 2015, Brainclinics Education and Brainclinics Treatment were acquired by the neuroCare Group, where courses are still taught by neuroCademy, and neuromodulation treatments that followed from Brainclinics Research are offered in >15 neuroCare clinics worldwide.

Independence

The most important pillar of our philosophy and mission is independence. Our non-profit foundation status ensures it is all about knowledge creation and content and our independence from companies and universities, but collaboration with companies and universitites ensures we conduct research independently and free of bias,  but is focused on clinical relevance, or as stated in our misison: Applied Neuroscience from the clinic, to the clinic!

Biological Psychiatry Australia (BPA) coming to beautiful Newcastle/Awabakal this Oct 30 - Nov 1st

@biolpsychaust

Submit your symposium proposals here:

http://www.biolpsychaustralia.com.au/annual-conferences/submissions/symposium-proposals/

Our latest paper is out in @APA_Publishing American Journal of Psychiatry! In this study, we explore the predictive value of rTMS-induced changes in functional connectivity for folks with treatment-resistant depression using concurrent rTMS-fMRI. 1/8

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Predictive Value of Acute Neuroplastic Response to rTMS in Treatment Outcome in Depression: A Concurrent TMS-fMRI Trial

Objective: The study objective was to investigate the predictive value of functional connectivity changes induced by a...

ajp.psychiatryonline.org

Newest pub! MPFC TBS for alcohol use disorder
#neuromodulation #TMS #alcohol
Real TBS (plus behavioral therapy)= 3.09 times more likely to remain sober 3 months after treatment initiation. Reduced MPFC-insula/striatum connectivity 2 and 3 months after TBS https://www.sciencedirect.com/science/article/pii/S2667174322000271

Our beloved MRI (N=300) and cognitive (N=2k) longitudinal dataset on adolescence is freely available. A huge acquisition, processing and curation effort. Enjoy it at http://nspn.org.uk ! https://twitter.com/rai_bethlehem/status/1524975515693887488

Twitter feed video.
Richard Bethlehem @rai_bethlehem

Years of work by an amazing team from @psychiatry_ucam and @UCLPsychiatry, funded by @wellcometrust and @CambridgeBRC released into the wild! https://nspn.org.uk/ A deeply phenotyped, comprehensive longitudinal assessment of adolescence. #openscience #mri #brains #nspn

@WilliamsNeuro @AcademicEEG At we open-sourced TD-BRAIN containing resting-state EEGs of 1243 participants (of which 141 with ADHD, some multiple recordings --> 271 datasets, but also MDD (n=426) and OCD (n=75)). More info in the participants files and the preprint. Happy datamining!

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resources - Brainclinics

www.brainclinics.com

The scientific consensus is consistent and unified in favor of Permanent Standard Time (#pST). #locktheclock for human health and safety.

Look forward to present our latest work on TMS induced heart-brain coupling (NCG-TMS 2.0), @CTMSSTAKESCHICAGO22
Not only can we identify best prefrontal site to target the frontal-vagal pathway, but also establish individualised frontal excitability thresholds (instead of MT)!

An EEG based biomarker that predicts remission to drug and neurofeedback treatment to ADHD. Collaborative work bringing together 6 global datasets with >5K ADHD samples. Study conceptualised and led by @Brainclinics and @HVoetterl https://twitter.com/Brainclinics/status/1522121961094189057

Martijn Arns @Brainclinics

First clinically actionable biomarker in largest ADHD EEG study: Brainmarker-I differentially predicts +30% remission to Methylphenidate and neurofeedback, after blinded out-of-sample validation.
Just published in Biological Psychiatry CNNI.

https://doi.org/10.1016/j.bpsc.2022.02.007

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🚨New Research🚨
Our paper looking at whether circadian rhythm derived from smartphone GPS data predicts #mentalhealth health and social functioning in people with #depression and #bipolar disorder is out now in @jmirpub's @JMIR_JMH
🧵

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Smartphone Sensor Data for Identifying and Monitoring Symptoms of Mood Disorders: A Longitudinal Observational Study

Background: Mood disorders are burdensome illnesses that often go undetected and untreated. Sensor technologies within s...

mental.jmir.org

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