The Brainclinics Foundation

Scientific research

Brainclinics was founded in 2001 as an independent research institute by dr. Martijn Arns and specializes in advancing our understanding of the brain; applied neuroscience to advance rTMS techniques, and ADHD and depression research. The results of our research are a valuable aid in the treatment and prevention of symptoms such as mood-, concentration-, impulse control-, and sleep problems, often seen in disorders such as depression, ADHD, and insomnia.

Forward thinking

Over the last 20 years, Brainclinics has pioneered the application of neurofeedback in the treatment of ADHD and insomnia, was one of the first to recognize the importance of the circadian clock and sleep problems underlying many symptoms like impaired concentration and impulse control, specifically in ADHD, while also pioneering and refining magnetic brain stimulation (rTMS) in the treatment of depression and obsessive–compulsive disorder (OCD) and in 2017 invented Neuro-Cardiac-Guided TMS to more specifically target the Frontal-Vagal network in Depression. In 2019 the legal structure was changed, and the non-profit Brainclinics Foundation was established.


The Brainclinics Foundation’s primary mission is best summarized as: Applied Neuroscience from the clinic, to the clinic. Therefore, the two pillars of the foundation are formed by the independent Research Institute Brainclinics and Brainclinics Insights (the publishing division).

applied neuroscience

Personalized medicine

At Research Institute Brainclinics researchers have published over 170 scientific publications on these and related topics and continue to collaborate with researchers and universities around the world ranging from Australia, Germany, Belgium, the United States to Colombia. A key topic of our research revolves around ‘personalized medicine’, going beyond the traditional ‘diagnostic-thinking’ and focusing on individual differences that can help optimize and individualize treatment and prevent symptoms from occurring.

Brainclinics Insights: Publishing and interactive media

Brainclinics Insights is the publishing division of our foundation. Its mission is to make the knowledge, expertise and especially ‘Insights’ gained through our research, widely available through books, PhD theses and interactive media. As an example, you can here find our latest documentary series titled ‘Pioneers of the EEG’ as well as various books and PhD-theses’ that are also published in the Apple bookstore. If you want to keep up-to-date, also make sure to follow our informative Youtube channel.

To serve the goal of the Brainclinics Foundation, all proceeds are fully invested into Research Institute Brainclinics and Brainclinics Insights, which creates an unprecedented synergy between these divisions and makes it possible to perform research and share new future insights into applied neuroscience as well.

At the Brainclinics Foundation, it is all about the research and its application!


Our research has resulted in 4 patents and several spin-offs, such as Brainquiry, where the first ever wireless Bluetooth based EEG amplifier was developed in 2003 and the first wrist-worn heart-rate device in 2005 (nine years before Apple launched the Apple Watch with similar technology). Other spin-offs are Brainclinics Education, where specialistic applied neuroscience training courses were developed focused on rTMS, neurofeedback and QEEG, and Brainclinics Treatment, where our unequalled knowledge and expertise on personalized neuromodulation treatments are applied to benefit people worldwide. In 2015, Brainclinics Education and Brainclinics Treatment were acquired by the neuroCare Group, where courses are still taught by neuroCademy, and neuromodulation treatments that followed from Brainclinics Research are offered in >15 neuroCare clinics worldwide.


The most important pillar of our philosophy and mission is independence. Our non-profit foundation status ensures it is all about knowledge creation and content and our independence from companies and universities, but collaboration with companies and universitites ensures we conduct research independently and free of bias,  but is focused on clinical relevance, or as stated in our misison: Applied Neuroscience from the clinic, to the clinic!

Episode 6 "Pioneers of the EEG" in Spanish. Edgar Douglas Adrian's contribution. Share this video with your friends, subscribe to the YouTube channel, and give us a "like" :). Thanks, @Brainclinics @FutuMark https://www.youtube.com/watch?v=RfOu7WnffvI

Dr Lennart Verhagen of the Donders Institute leads a fascinating introduction to the mechanisms behind transcranial focused ultrasound neuromodulation in this webinar. Highly recommended viewing for anyone new to #TUS.

#neuroscience #neuromodulation

TMS for analgesia: intriguing work by @thexche

What is the optimal rTMS #pulses & frequency?

Less might be more, in line w recent work by
@brainstimgrl (TBS) & in contrast to clin guidelines

Also, interesting correlations btw 10Hz condts but not 20Hz!

Just published in @brainstimj by @L_Zwienenberg et al.
Neuro-Cardiac Guided rTMS as a stratifying method between the ‘5cm’ and ‘BeamF3’ stimulation clusters.
Incl. another replication in MDD patients.


Prolonged pain lowers the peak alpha frequency activity of an individual by suppressing fast (10-12 Hz) alpha power. This could account for why chronic pain patients have a lower peak alpha frequency.

Arns & Voetterl: The findings from Voineskos and colleagues regarding the more focal left DLPFC TEP amplitude so strongly predicting suicidality response to rTMS treatment are novel and intriguing.

Editorial: https://doi.org/10.1016/j.clinph.2021.06.010
Voineskos et al. 2021: https://doi.org/10.1016/j.clinph.2021.05.008

Triple chronotherapy has been proposed as a treatment for Non-24-Hour Sleep-Wake Disorder. It consists of total sleep deprivation, nocturnal melatonin, and morning bright light therapy to re-entrain to a 24 hour sleep / wake cycle. #circadian

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