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The Brainclinics Foundation

Scientific research

Brainclinics was founded in 2001 as an independent research institute by dr. Martijn Arns and specializes in advancing our understanding of the brain; applied neuroscience to advance rTMS techniques, and ADHD and depression research. The results of our research are a valuable aid in the treatment and prevention of symptoms such as mood-, concentration-, impulse control-, and sleep problems, often seen in disorders such as depression, ADHD, and insomnia.

Forward thinking

Over the last 20 years, Brainclinics has pioneered the application of neurofeedback in the treatment of ADHD and insomnia, was one of the first to recognize the importance of the circadian clock and sleep problems underlying many symptoms like impaired concentration and impulse control, specifically in ADHD, while also pioneering and refining magnetic brain stimulation (rTMS) in the treatment of depression and obsessive–compulsive disorder (OCD) and in 2017 invented Neuro-Cardiac-Guided TMS to more specifically target the Frontal-Vagal network in Depression. In 2019 the legal structure was changed, and the non-profit Brainclinics Foundation was established.

Mission

The Brainclinics Foundation’s primary mission is best summarized as: Applied Neuroscience from the clinic, to the clinic. Therefore, the two pillars of the foundation are formed by the independent Research Institute Brainclinics and Brainclinics Insights (the publishing division).

applied neuroscience

Personalized medicine

At Research Institute Brainclinics researchers have published over 170 scientific publications on these and related topics and continue to collaborate with researchers and universities around the world ranging from Australia, Germany, Belgium, the United States to Colombia. A key topic of our research revolves around ‘personalized medicine’, going beyond the traditional ‘diagnostic-thinking’ and focusing on individual differences that can help optimize and individualize treatment and prevent symptoms from occurring.

Brainclinics Insights: Publishing and interactive media

Brainclinics Insights is the publishing division of our foundation. Its mission is to make the knowledge, expertise and especially ‘Insights’ gained through our research, widely available through books, PhD theses and interactive media. As an example, you can here find our latest documentary series titled ‘Pioneers of the EEG’ as well as various books and PhD-theses’ that are also published in the Apple bookstore. If you want to keep up-to-date, also make sure to follow our informative Youtube channel.

To serve the goal of the Brainclinics Foundation, all proceeds are fully invested into Research Institute Brainclinics and Brainclinics Insights, which creates an unprecedented synergy between these divisions and makes it possible to perform research and share new future insights into applied neuroscience as well.

At the Brainclinics Foundation, it is all about the research and its application!

Results

Our research has resulted in 4 patents and several spin-offs, such as Brainquiry, where the first ever wireless Bluetooth based EEG amplifier was developed in 2003 and the first wrist-worn heart-rate device in 2005 (nine years before Apple launched the Apple Watch with similar technology). Other spin-offs are Brainclinics Education, where specialistic applied neuroscience training courses were developed focused on rTMS, neurofeedback and QEEG, and Brainclinics Treatment, where our unequalled knowledge and expertise on personalized neuromodulation treatments are applied to benefit people worldwide. In 2015, Brainclinics Education and Brainclinics Treatment were acquired by the neuroCare Group, where courses are still taught by neuroCademy, and neuromodulation treatments that followed from Brainclinics Research are offered in >15 neuroCare clinics worldwide.

Independence

The most important pillar of our philosophy and mission is independence. Our non-profit foundation status ensures it is all about knowledge creation and content and our independence from companies and universities, but collaboration with companies and universitites ensures we conduct research independently and free of bias,  but is focused on clinical relevance, or as stated in our misison: Applied Neuroscience from the clinic, to the clinic!

Final PDF’s just published!
The first two replication studies from the ICON-DB consortium.… a thread.
1) First study replicates the alpha frequency proximity to the TMS stimulation frequency for 10 Hz as originally reported by Corlier et al.

https://doi.org/10.1016/j.clinph.2020.10.017

Just published: First results of double-blind placebo controlled RCT on Theta/Beta neurofeedback in ADHD. Primary outcome not met, but overall large and lasting improvements, also see graphical abstract.
@JAACAP

https://authors.elsevier.com/c/1c6bU3AZg~N2pp

Image for the Tweet beginning: Just published: First results of

[Obituary] van Putten et al.: “In Memoriam: Fernando Lopes da Silva (1935–2019).”
http://doi.org/10.1016/j.clinph.2019.08.024

One of his papers [http://doi.org/10.1016/0013-4694(91)90044-5] has been cited more than 1200 times. #ClinicalNeuroph

Image for the Tweet beginning: [Obituary] van Putten et al.:

Recently published in @natBME by Amit Etkin’s group: Identification of psychiatric disorder subtypes from functional connectivity patterns in resting-state EEG.

Great example of power of EEG as a treatment stratification tool, also cross-disorder!

https://www.nature.com/articles/s41551-020-00614-8

Image for the Tweet beginning: Recently published in @natBME by

Sleep: slow wave activity predicts Amyloid beta
accumulation

https://www.sciencedirect.com/science/article/pii/S0960982220314287

Image for the Tweet beginning: Sleep: slow wave activity predicts

[TMS for Depression] Bailey et al.: "Baseline resting EEG theta connectivity or alpha power are unlikely to be generalisable predictors of response to rTMS treatment for depression."

https://doi.org/10.1016/j.clinph.2020.10.018
#ClinicalNeuroph #TMS #Depression @Epworth @MonashUni @CCSMonash

Image for the Tweet beginning: [TMS for Depression] Bailey et

learning about neuroCardiacGuided-rTMS at #BSiP - thanks for the talk @Brainclinics & cooperation

https://youtu.be/cJInBUqwPHQ

[TMS for Depression] Roelofs et al.: "rTMS treatment outcome is quadratically related to the individual alpha peak frequency (IAF) in depression."

https://doi.org/10.1016/j.clinph.2020.10.017

#ClinicalNeuroph #TMS #Depression @Brainclinics @PsyMaastricht @MaastrichtU

Image for the Tweet beginning: [TMS for Depression] Roelofs et
Image for the Tweet beginning: [TMS for Depression] Roelofs et

Interesting DGKN Online Session on Neurophysiology in Psychiatry. Very clinical, from sleep EEG, EEG in diagnostics, EEG in treatment prediction to Neurofeedback.
https://www.dgkn-kongress2020.de/en/general-information/ausblick-2021/

Image for the Tweet beginning: Interesting DGKN Online Session on

We’re ready for tomorrow, all presentations are in, ‘see you’ online tomorrow for a great program!
Brain Stimulation in psychiatry, rTMS, tDCS and a great keynote discussion: To Biotype or not to Biotype with Conor Liston, Andre Marquand and Amit Etkin.
https://www.brain-stimulation.eu/

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