The Brainclinics Foundation

Scientific research

Brainclinics was founded in 2001 as an independent research institute by dr. Martijn Arns and specializes in advancing our understanding of the brain; applied neuroscience to advance rTMS techniques, and ADHD and depression research. The results of our research are a valuable aid in the treatment and prevention of symptoms such as mood-, concentration-, impulse control-, and sleep problems, often seen in disorders such as depression, ADHD, and insomnia.

Forward thinking

Over the last 20 years, Brainclinics has pioneered the application of neurofeedback in the treatment of ADHD and insomnia, was one of the first to recognize the importance of the circadian clock and sleep problems underlying many symptoms like impaired concentration and impulse control, specifically in ADHD, while also pioneering and refining magnetic brain stimulation (rTMS) in the treatment of depression and obsessive–compulsive disorder (OCD) and in 2017 invented Neuro-Cardiac-Guided TMS to more specifically target the Frontal-Vagal network in Depression. In 2019 the legal structure was changed, and the non-profit Brainclinics Foundation was established.


The Brainclinics Foundation’s primary mission is best summarized as: Applied Neuroscience from the clinic, to the clinic. Therefore, the two pillars of the foundation are formed by the independent Research Institute Brainclinics and Brainclinics Insights (the publishing division).

applied neuroscience

Personalized medicine

At Research Institute Brainclinics researchers have published over 170 scientific publications on these and related topics and continue to collaborate with researchers and universities around the world ranging from Australia, Germany, Belgium, the United States to Colombia. A key topic of our research revolves around ‘personalized medicine’, going beyond the traditional ‘diagnostic-thinking’ and focusing on individual differences that can help optimize and individualize treatment and prevent symptoms from occurring.

Brainclinics Insights: Publishing and interactive media

Brainclinics Insights is the publishing division of our foundation. Its mission is to make the knowledge, expertise and especially ‘Insights’ gained through our research, widely available through books, PhD theses and interactive media. As an example, you can here find our latest documentary series titled ‘Pioneers of the EEG’ as well as various books and PhD-theses’ that are also published in the Apple bookstore. If you want to keep up-to-date, also make sure to follow our informative Youtube channel.

To serve the goal of the Brainclinics Foundation, all proceeds are fully invested into Research Institute Brainclinics and Brainclinics Insights, which creates an unprecedented synergy between these divisions and makes it possible to perform research and share new future insights into applied neuroscience as well.

At the Brainclinics Foundation, it is all about the research and its application!


Our research has resulted in 4 patents and several spin-offs, such as Brainquiry, where the first ever wireless Bluetooth based EEG amplifier was developed in 2003 and the first wrist-worn heart-rate device in 2005 (nine years before Apple launched the Apple Watch with similar technology). Other spin-offs are Brainclinics Education, where specialistic applied neuroscience training courses were developed focused on rTMS, neurofeedback and QEEG, and Brainclinics Treatment, where our unequalled knowledge and expertise on personalized neuromodulation treatments are applied to benefit people worldwide. In 2015, Brainclinics Education and Brainclinics Treatment were acquired by the neuroCare Group, where courses are still taught by neuroCademy, and neuromodulation treatments that followed from Brainclinics Research are offered in >15 neuroCare clinics worldwide.


The most important pillar of our philosophy and mission is independence. Our non-profit foundation status ensures it is all about knowledge creation and content and our independence from companies and universities, but collaboration with companies and universitites ensures we conduct research independently and free of bias,  but is focused on clinical relevance, or as stated in our misison: Applied Neuroscience from the clinic, to the clinic!

Arns & Voetterl: The findings from Voineskos and colleagues regarding the more focal left DLPFC TEP amplitude so strongly predicting suicidality response to rTMS treatment are novel and intriguing.

Editorial: https://doi.org/10.1016/j.clinph.2021.06.010
Voineskos et al. 2021: https://doi.org/10.1016/j.clinph.2021.05.008

Triple chronotherapy has been proposed as a treatment for Non-24-Hour Sleep-Wake Disorder. It consists of total sleep deprivation, nocturnal melatonin, and morning bright light therapy to re-entrain to a 24 hour sleep / wake cycle. #circadian

Our editorial in @ClinicalNeuroph
Neurophysiological effects of rTMS: Revisiting the role of the N100 as a clinically useful marker in depression

Neurofeedback Past, Present & Future - my interview with @neuroconn
➡️ introducing EEG microstate-neurofeedback

RIP Joe Kamiya - the "grandfather" of neurofeedback, whose experiments in the 1960s showed that people can control their alpha brainwaves using real-time sensory feedback

In memoriam

We lost another leader in the sleep field, Dr. Allan Hobson, known for his work on sleep and dreams. 😧Check out World Sleep Society's tribute page: https://worldsleepsociety.org/in-memoriam-allan-hobson-m-d/

[MEG study] de Frutos-Lucas et al.: “Physical activity is positively associated to higher individual alpha peak frequency in healthy older adults and could potentially act as a protective factor against cognitive decline.”


Here one example. The colorbars show the group median coupling coefficients (for significant clusters after permutation tests against rest)

We implemented a mathematical model to estimate the mutual modulations between EEG and heart-rate oscillations. With the model we obtain a timecourse of the coupling coefficients for both directions

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