Since the goal is to develop clinically actionable biomarkers, that should generalize to ‘unseen’ data, we have marked 30% of clinical and treatment outcome data as REPLICATION and have a seperate validation set for diagnostic predictions. These are blinded for prospective validation and replication purposes. Interested researchers can share (This email address is being protected from spambots. You need JavaScript enabled to view it.) their diagnostic or treatment-outcome predictions with us, so we can perform a ‘blinded out-of-sample’ validation for them, and post the results on our website, so that reviewers for journals can also consult this independent validation of their algorithms. Conversely, reviewers or editors faced with ‘too good to be true’ claims, can refer researchers to this TDBRAIN resource, to perform validations and share them with us for verification and publication. We hope this will accelerate the discovery and validation of clinically actionable biomarkers that we hope will soon benefit patients and improve psychiatric and neurological care in the clinic.
Please use the TDBRAIN replication template (excel file, download here) when sharing the results with us, so we can perform for you a blinded out-of-sample validation.